
Proof of Concept for Protein-DNA Affinity Solution
Progenus
Challenge
Progenus, an innovative company specializing in genetic testing,
focuses on DNA research and development (R&D) in fields like animal husbandry,
agriculture, and the food industry. As a leader in the sector, Progenus is
consistently seeking ways to utilize cutting edge technologies to enhance
their operations and R&D efforts.
We assisted Progenus in tackling a key challenge related to
protein-DNA binding. The traditional method of conducting systematic
laboratory tests for this purpose was found to be both labor-intensive
and resource-heavy. Progenus was in need of a more streamlined solution
that would facilitate the process of identifying the DNA sequences most
likely to bind to a specific protein. Implementing such a solution would
significantly decrease the resources needed for the design and development
of new PCR tests.
Outcome
Despite the limited amount of available data, our team of
experts developed a custom artificial intelligence solution capable of
filtering a subset of ''high quality'' sequences for experimental testing.
Our results lead to an eight-fold decrease in the number of tests required
to determine optimal DNA/RNA sequences and the results were validated on
multiple proteins. We achieved this by leveraging custom machine learning
techniques and an innovative approach to engineer useful features from raw
DNA data, significantly enhancing the probability of suggesting experimentally
viable recommendations compared to standard selection techniques.
Conclusion
Our innovative AI-driven solution substantially improves
the accuracy of Progenus' DNA-protein binding pair recommendation system.
The solution saves time and resources, offering significant operational
improvement to Progenus, and a pathway towards more efficient and cheaper
genetic tests.